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KMID : 0616120090400020128
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 2 p.128 ~ p.136
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Antidiabetic and Antioxidative Effect of Lycii fructus in Streptozotocin-Induced Diabetic Rats
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Kim Ok-Kyung
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Abstract
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This study was carried out to investigate the antidiabetic and antioxidative effect of Lycii fructus in the Streptozotocin(STZ)-induced diabetic rats. The effective fractions were prepared as a form of organic solvents of , EtOAc, BuOH and fractions prepared from the EtOH extract of Lycii fructus and The diabetes were induced by an tail-intravenous injection of STZ with a dose of 45 mg/kg dissolved in citrate buffer. The various fractions of Lycii fructus were orally administrated once a day for 7 days. The contents of serum glucose, and triglyceride in the fraction and hepatic lipid peroxidation in the EtOAc, BuOH and fractions treated rats were significantly decreased when compared to those of the STZ-control group In addition, an activity of hepatic GST in the BuOH fraction treated rats was significantly increased compared to that of the STZ-control group. whereas, activities of hepatic catalase, GSH-Px in the BuOH fraction treated rats were significantly decreased compared to those of the STZ-control group. Meanwhile, The content of hepatic glycogen and avtivity of hepatic glucokinase in fraction treated rats were significantly increased, but activity of glucose-6-pase was significantly decreased in the fraction treated rats. In conclusion, these results indicated that the BuOH fraction of Lycii fructus was effective for the antioxidation, and also the fraction of Lycii fructus was effective for the antidiabetes in the STZ-induced diabetic rats.
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KEYWORD
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Streptozotocin, Lycii, fructus, Antidiabetic and Antioxidative effect
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